A cerium oxide@metal-organic framework nanoenzyme as a tandem catalyst for enhanced photodynamic therapy

Chem Commun (Camb). 2021 Feb 19. doi: 10.1039/d1cc00001b. Online ahead of print.ABSTRACTAn O2 self-evolving core-shell theranostic nanohybrid was developed by encapsulating a nanoenzyme cerium oxide (CeOx) in a metal-organic framework (MOF). The hybrid reveals a 9-fold higher apoptotic percentage than bare CeOx in a harsh hypoxic microenvironment through tandem homogenous catalysis. Simultaneously, the oxygen-promoted therapeutic efficiency was self-monitored by the hybrid with caspase-3 activation, paving the way for MOF-functionalized nanoenzymes in theranostics.PMID:33605969 | DOI:10.1039/d1cc00001b
Source: Chemical Communications - Category: Chemistry Authors: Source Type: research