pH-Dependent ion permeability control of a modified amphotericin B channel through metal complexation

Chem Commun (Camb). 2021 Feb 19. doi: 10.1039/d0cc08368b. Online ahead of print.ABSTRACTAmphotericin B incorporating 2,2'-bipyridine (bpy-AmB) forms a membrane channel exhibiting pH-dependent Ca2+ ion permeability with a selective response to Cu2+ ions. The coordination structure at bpy sites depends on the pH and metal ions can control the association state of bpy-AmB in the membrane.PMID:33606865 | DOI:10.1039/d0cc08368b

Source: Chemical Communications - February 19, 2021 Category: Chemistry Authors: Tomomi Koshiyama Yuki Inoue Sana Asada Koki Kawahara Shogo Ide Kazuma Yasuhara Masaaki Ohba Source Type: research