Interfacial cationization to quicken redox-responsive drug release

Chem Commun (Camb). 2021 Feb 23. doi: 10.1039/d1cc00156f. Online ahead of print.ABSTRACTInterfacial cationization could greatly increase the redox-responsiveness of disulfide bond-linked lipid-drug nanoassemblies (NAs) due to the generation and concentration of ionized thiols at the alkalized NAs' cationic interface. This strategy could be used to prepare redox-ultrasensitive nanocarriers for efficient intracellular drug delivery.PMID:33621308 | DOI:10.1039/d1cc00156f

Source: Chemical Communications - February 23, 2021 Category: Chemistry Authors: Yaxin Zheng Jie Lei Qi Li Xuan Jin Qingyuan Li Yang Li Source Type: research