Suggestions for global coagulation assays for the assessment of COVID-19 associated hypercoagulability

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV2) infection is associated with a clear prothrombotic phenotype. Although the exact pathophysiological mechanisms are not yet fully understood, thrombosis is clearly a highly important in the prognosis and outcome of COVID-19. As such, there is a need for diagnostic analysis and quantification of the coagulation potential in these patients, both at diagnosis and follow-up. Global coagulation assays like thrombin generation (TG) and rotational thromboelastometry (ROTEM) might be suitable in estimating COVID-19 associated coagulopathy and thrombosis risk.

Source: Thrombosis Research - February 24, 2021 Category: Hematology Authors: T.W. van de Berg, A.M. Hulshof, Magdolna Nagy, Rene van Oerle, Jan-Willem Sels, Bas van Bussel, Hugo ten Cate, Yvonne Henskens, Henri M.H. Spronk, Dutch Covid-19 and Thrombosis Coalition (DCTC) Tags: Full Length Article Source Type: research