Associations of Omega-3 fatty acids with brain morphology and volume in cognitively healthy older adults: A narrative review

CONCLUSION: The search identified only 12 studies, 8 of which were cross-sectional observational studies, 3 longitudinal observational studies, and 1 randomized controlled trial published between 2007 and 2019. The largest amount of evidence indicated that the hippocampus was most frequently involved in this association, with a higher volume associated with higher omega-3 levels. Larger total grey matter, total brain volume, and lower white matter lesion volume were also associated with higher omega-3 among four of the reviewed studies. However, most studies reviewed provided mixed findings regarding the presence or absence of the association of interest, and the findings were observed to be brain region-dependent. Current evidence is still insufficient to formulate recommendations for omega-3 intake to support brain health specifically.PMID:33607289 | DOI:10.1016/j.arr.2021.101300
Source: Ageing Research Reviews - Category: Genetics & Stem Cells Authors: Source Type: research