COVID-19 mortality as a fingerprint of biological age

Ageing Res Rev. 2021 Feb 20:101308. doi: 10.1016/j.arr.2021.101308. Online ahead of print.ABSTRACTCorona virus disease 2019 (COVID-19) is a global emergency able to overwhelm the healthcare capacities worldwide and to affect the older generation especially. When addressing the pathophysiological mechanisms and clinical manifestations of COVID-19, it becomes evident that the disease targets pathways and domains affected by the main aging- and frailty-related pathophysiological changes. A closer analysis of the existing data supports a possible role of biological age rather than chronological age in the prognosis of COVID-19. There is a need for systematic, consequent action of identifying frail (not only older, not only multimorbid, not only symptomatic) persons at risk of poor outcomes in order to protect our oldest generation from COVID-19.PMID:33621704 | DOI:10.1016/j.arr.2021.101308
Source: Ageing Research Reviews - Category: Genetics & Stem Cells Authors: Source Type: research