Kynurenine 3-monooxygenase deficiency induces depression-like behavior via enhanced antagonism of α7 nicotinic acetylcholine receptors by kynurenic acid

In conclusion, elevation of KA levels contributes to depression-like behaviors in KMO KO mice by α7nAChR antagonism. The ameliorating effects of nicotine and galantamine on depression-like behaviors in KMO KO mice are associated with the activation of α7nAChR.PMID:33607168 | DOI:10.1016/j.bbr.2021.113191

Source: Behavioural Brain Research - February 19, 2021 Category: Neurology Authors: Yuko Mori Akihiro Mouri Kazuo Kunisawa Mami Hirakawa Hisayoshi Kubota Aika Kosuge Moe Niijima Masaya Hasegawa Hitomi Kurahashi Reiko Murakami Masato Hoshi Takashi Nakano Suwako Fujigaki Hidetsugu Fujigaki Yasuko Yamamoto Toshitaka Nabeshima Kuniaki Saito Source Type: research