Eltrombopag restores erythropoiesis in refractory adult acquired pure red cell aplasia

Int J Hematol. 2021 Feb 21. doi: 10.1007/s12185-021-03100-2. Online ahead of print.ABSTRACTAcquired pure red cell aplasia is a rare condition characterized by normocytic normochromic anemia with severe reticulocytopenia. In refractory acquired pure red cell aplasia, the low response rate of immunosuppressive therapy also constitutes a challenge. We herein report the case of a 58-year-old male with refractory acquired pure red cell aplasia that was successfully treated by eltrombopag at a dose of 75 mg/day. After application of eltrombopag, the patient achieved complete remission and tolerated the treatment very well, with only mild bilirubin elevation. These preliminary findings showed that eltrombopag may be effective and well tolerated in adult patients with refractory acquired pure red cell aplasia.PMID:33611753 | DOI:10.1007/s12185-021-03100-2

Source: International Journal of Hematology - February 21, 2021 Category: Hematology Authors: Xiaoqing Liu Lang Cheng Yao He Run Zhang Ruinan Lu Jianfu Zhang Ming Hong Guangsheng He Jianyong Li Source Type: research