Baclofen to Prevent Agitation Caused by Alcohol Withdrawal in the ICU

Alcohol use and abuse is common in many societies and is associated with adverse effects on health. According to the US National Institute on Alcohol Abuse and Alcoholism, in 2019, an estimated 14.1 million adults aged 18 years and older had alcohol use disorder, defined as “chronic relapsing brain disease characterized by an impaired ability to stop or control alcohol use despite adverse social, occupational, or health consequences.” Among the numerous alcohol-related diseases and harms, including liver cirrhosis, obesity, some cancers, injury, and suicide, only s ome directly contribute to acute critical illness. However, among patients with alcohol use or abuse who require intensive care unit (ICU) or hospital admission, alcohol withdrawal is an important factor that may complicate treatment and increase the risk of adverse outcomes.
Source: JAMA - Category: General Medicine Source Type: research

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The rate at which suicide and mental health challenges are plaguing our society tells me it ’s time for business leaders to reinvest in rebuilding our human infrastructure, writes Kevin McCain.
Source: bizjournals.com Health Care News Headlines - Category: Health Management Authors: Source Type: news
ConclusionThere is no association between early initiation of adjuvant chemotherapy and post-operative complications including wound healing. Early initiation of chemotherapy ( ≤ 7 days) is feasible in unilateral WT or high-risk neuroblastoma patients who are otherwise doing well without resulting in a preponderance of wound healing complications.
Source: Pediatric Surgery International - Category: Surgery Source Type: research
Sad case here: Suicide [Naturopathic "Doctor"] Young woman with suicidal thoughts. Takes her husband's gun, holds it to her head. Tells family, they try to help her but she is resistant to hospitalization. Sees a naturopathic doctor, apparently there was no screening for suicidality. Dies by suicide several weeks later. Husband sues multiple providers (psychiatrist who had seen her months before, social worker, naturopathic doctor). Everyone eventually ends up settling.
Source: Student Doctor Network - Category: Universities & Medical Training Authors: Tags: Psychiatry Source Type: forums
Purpose of review This review highlights recent research advances regarding the pathophysiology and treatment of gastroparesis. Recent findings Differences in brain activity have been identified on functional MRI imaging in gastroparesis patients with nausea. Abdominal pain is common in patients with gastroparesis and does not correlate with the severity of gastric emptying delay, though may be associated with depression and anxiety. Autonomic dysfunction may play an important role in the pathophysiology of gastroparesis. There is increasing sentiment that gastroparesis should be considered a part of the same sp...
Source: Current Opinion in Gastroenterology - Category: Gastroenterology Tags: STOMACH AND DUODENUM: Edited by Tilak U. Shah Source Type: research
Purpose of review Gastric intestinal metaplasia (GIM) is an attractive target for surveillance and treatment as it can progress to gastric adenocarcinoma (GAC). Yet, GIM remains a challenging area for clinicians as most patients do not progress to cancer, and there are conflicting data regarding the benefits of surveillance and therapy. This review aims to summarize recently published GIM surveillance guidelines, to discuss, which patients with GIM may benefit from treatment, and to review pivotal and recent literature on GIM therapy. Recent findings Guidelines published by American, British, and European gastro...
Source: Current Opinion in Gastroenterology - Category: Gastroenterology Tags: STOMACH AND DUODENUM: Edited by Tilak U. Shah Source Type: research
Purpose of review To review studies from 2020 to 2021 in esophagogastric cancer. Recent findings After up front D2 gastrectomy for lymph node-positive gastric cancer, 6 months of adjuvant chemotherapy with S-1 and oxaliplatin achieved superior disease-free survival (DFS) compared with 1 year of S-1. The addition of adjuvant radiotherapy, however, added no benefit. After chemoradiotherapy and surgery in esophageal and gastroesophageal junction cancer, in patients with residual disease found at surgery, 1 year of adjuvant nivolumab substantially improved DFS compared with observation alone, leading to regulatory a...
Source: Current Opinion in Gastroenterology - Category: Gastroenterology Tags: STOMACH AND DUODENUM: Edited by Tilak U. Shah Source Type: research
Purpose of review Gastric cancer remains one of the most common causes of death globally. Increasing evidence suggests that many gastric cancer cases can be prevented by eradicating its most important etiological agent, Helicobacter pylori. Using the search terms ‘H. pylori’ and ‘gastric cancer’ we reviewed the scientific literature regarding the association between H. pylori and gastric cancer published from 1 January 2020 to 30 May 2021. We review the most important articles relevant to the clinical issues regarding H. pylori eradication for gastric cancer prevention. Recent findings In...
Source: Current Opinion in Gastroenterology - Category: Gastroenterology Tags: STOMACH AND DUODENUM: Edited by Tilak U. Shah Source Type: research
Source: Cancer Management and Research - Category: Cancer & Oncology Tags: Cancer Management and Research Source Type: research
Source: Cancer Management and Research - Category: Cancer & Oncology Tags: Cancer Management and Research Source Type: research
Source: Cancer Management and Research - Category: Cancer & Oncology Tags: Cancer Management and Research Source Type: research
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