Leucovorin Rescue After Methotrexate Graft-Versus-Host Disease Prophylaxis Shortens the Duration of Mucositis, Time to Neutrophil Engraftment, and Hospital Length of Stay

Oropharyngeal mucositis (OPM) is common following conditioning for allogeneic hematopoietic cell transplantation (alloHCT) and results in pain, functional status decline, need for nutritional support, infections, and prolonged length of stay (LOS). Methotrexate (MTX) graft-versus-host disease (GVHD) prophylaxis exacerbates OPM and slows hematopoietic engraftment, which may prolong the LOS. Previous studies have demonstrated reduced OPM and more rapid engraftment when leucovorin (LCV) is added following MTX GVHD prophylaxis, yet this practice is controversial.

https://www.tctjournal.org/article/S2666-6367(21)00637-0/fulltext?rss=yes

Source: Biology of Blood and Marrow Transplantation - February 4, 2021 Category: Hematology Authors: Craig W. Freyer, Shannon Gier, Mary E. Moyer, Natasha Berryman, Alison Carulli, Alex Ganetsky, Colleen Timlin, Daria V. Babushok, Noelle V. Frey, Saar I. Gill, Elizabeth O. Hexner, Alison W. Loren, James K. Mangan, Mary Ellen Martin, Shannon McCurdy, Alex Source Type: research