Single Nuclei Sequencing Reveals Novel Insights into the Regulation of Cellular Signatures in Children with Dilated Cardiomyopathy

Conclusions: Novel insights into the cellular transcriptomes of hearts from pediatric DCM patients provide remarkable age-dependent changes in the expression patterns of fibroblast and cardiomyocyte genes with less fibrotic but enriched pro-regenerative signatures in infants.PMID:33618539 | DOI:10.1161/CIRCULATIONAHA.120.051391

Source: Circulation - February 23, 2021 Category: Cardiology Authors: Luka Nicin Wesley T Abplanalp Anne Sch änzer Anke Sprengel David John Hannah Mellentin Lukas Tombor Matthias Keuper Evelyn Ullrich Karin Klingel Reinhard B Dettmeyer Jedrzej Hoffmann Hakan Akintuerk Christian Jux Dietmar Schranz Andreas M Zeiher Stefan R Source Type: research