Machine learning method identifies precancerous colon polyps

(Radiological Society of North America) A machine learning algorithm helps accurately differentiate benign and premalignant colorectal polyps on CT colonography scans, according to a new study.
Source: EurekAlert! - Cancer - Category: Cancer & Oncology Source Type: news

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Scand J Gastroenterol. 2021 Jul 3:1-9. doi: 10.1080/00365521.2021.1922744. Online ahead of print.ABSTRACTAIMS: Epigenetic alterations of genes involved in colorectal carcinogenesis are likely to be informative biomarkers for early detection. We assessed the methylation profile of a panel of seven colon cancer-related genes comparing normal colon, colorectal cancer (CRC) precursor lesions and cancer tissues from a Brazilian cohort.METHODS: The cohort comprised 114 CRC patients, including 40 matched normal tissue, 47 patients with adenomas, 33 with serrated polyps and 8 with normal colonic biopsy. DNA methylation status of S...
Source: Scandinavian Journal of Gastroenterology - Category: Gastroenterology Authors: Source Type: research
CONCLUSIONS: This study reports a high dysplasia detection rate (24%) via targeted chromoendoscopic biopsies. In most cases, lesions were successfully removed by endoscopic resection. Our results underline the importance of colorectal cancer surveillance in inflammatory bowel disease patients.PMID:33905275 | DOI:10.1080/00365521.2021.1918758
Source: Scandinavian Journal of Gastroenterology - Category: Gastroenterology Authors: Source Type: research
Conclusion We demonstrated that a novel 3 D optical scanning system improves the performance of colonoscopy procedures by using a combination of 3 D and 2 D optical scanning and fast, accurate software for extracting data and generating models. Further studies of the system are warranted. [...] Georg Thieme Verlag KG Rüdigerstraße 14, 70469 Stuttgart, GermanyArticle in Thieme eJournals: Table of contents  |  Abstract  |  open access Full text
Source: Endoscopy International Open - Category: Gastroenterology Authors: Tags: Original article Source Type: research
A 78-year-old man with a sigmoidectomy history for pT2N0M0 colon adenocarcinoma presented with elevated carcinoembryonic antigen. 18F-fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDG PET/CT) was performed for comprehensive evaluation which indicated multiple high FDG uptake lesions suspicious for malignancy (Fig.  1). Subsequent esophagogastroduodenoscopy (EGD) and colonoscopy respectively revealed a 30-mm semipedunculated polypoid lesion in the duodenum and an 8-mm sessile polyp in the ascending colon (Fig. 2) but without the sign of anastomotic recurrence.
Source: Digestive and Liver Disease - Category: Gastroenterology Authors: Tags: Image of the Month Source Type: research
A collaboration between researchers at Nanyang Technological University, Harvard Medical School, and University of Alabama has led to the development of a prototype device capable of imaging through tissues at resolutions down to 1 micrometer (μm)...
Source: Medgadget - Category: Medical Devices Authors: Tags: Dermatology Diagnostics GI Oncology Pathology Radiology Source Type: blogs
AbstractThe aim of the study was to evaluate the ability to detect extra-cardiac foci by means of whole-body18F-fluorodeoxyglucose positron emission tomography/computed tomography (FDG-PET/CT) in patients with definite endocarditis (IE) according to the modified Duke criteria and investigate the clinical impact of the findings. From January 2011 to December 2015 we included 178 patients (mean age 66  ± 14 years, 25% female) with IE in this multicentre study. FDG-PET/CT was part of the work-up for extra-cardiac foci in the including hospitals and was performed at a median of 9 days (IQR 10) af...
Source: The International Journal of Cardiovascular Imaging - Category: Radiology Source Type: research
Gore Has a New Challenger in SFA PQ Bypass is set to become the first company since 2004 to have an IDE trial for a stent to treat peripheral artery disease in the superficial femoral artery (SFA). If all goes as planned for the company, its Torus Stent Graft will compete head-to-head with W.L. Gore's Viabahn system. PQ Bypass could potentially file for FDA approval in 2021.   Should This Blood Test Be Part of the Standard Pre-Op for Most Surgeries? A common cardiac blood test done before surgery can predict who will experience adverse outcomes after most types of surgery, said researchers from Hami...
Source: MDDI - Category: Medical Devices Authors: Tags: Business Source Type: news
Abstract While colonoscopy is considered the gold standard for colon cancer screening, recent advancements in endoscopes have allowed for improved visualization of the colonic mucosa and improved polyp detection rates. Newer technologies also allow for assessment of structural changes for polyp discrimination and determination of histologic type. Classification of polyps prevents the need for a histopathologic report, which requires the additional time and expertise of a pathologist and adds to the overall cost. This review considered advances in endoscopic technologies reported in PubMed over the past 12 years. T...
Source: Baylor University Medical Center Proceedings - Category: Universities & Medical Training Authors: Tags: Proc (Bayl Univ Med Cent) Source Type: research
Check-Cap Ltd. is reporting positive results from a pilot study of its C-Scan System. The Isfiya, Israel-based company’s C-Scan System is a preparation-free ingestible scanning capsule-based system for the prevention of colorectal cancer through the detection of precancerous polyps. Results from the pilot study show that no device or procedure-related serious adverse events were reported and all device or procedure-related adverse events were mild in severity. In total, 45 patients enrolled in the study, of which 40 patients underwent the study procedure. All 40 patients complied with the procedure and co...
Source: MDDI - Category: Medical Devices Authors: Tags: Imaging Digital Health Source Type: news
Check-Cap ’s swallow-able capsule uses low-dose x-rays to screen the digestive system while it moves along the GI tract. These scans are used to primarily detect precancerous polyps in the colon, making the capsule a preventative test, not a cancer treatment.
Source: Healthcare News - Category: Pharmaceuticals Authors: Source Type: news
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