Heritability of Ethanol Consumption and Pharmacokinetics in a Genetically Diverse Panel of Collaborative Cross Mouse Strains and Their Inbred Founders

CONCLUSIONS: Collectively, this research may serve as a foundation for expanded genetic study of ethanol consumption in the CC/DO and related populations; moreover, we have identified reference strains with extreme consumption phenotypes that effectively represent polygenic models of excessive ethanol use.PMID:33619752 | DOI:10.1111/acer.14582

Source: Alcoholism, Clinical and Experimental Research - February 23, 2021 Category: Addiction Authors: Jared R Bagley Elissa J Chesler Vivek M Philip Center for the Systems Genetics of Addiction James D Jentsch Source Type: research