Determining the incidence of interstitial pneumonitis and chronic kidney disease following full intensity haemopoetic stem cell transplant conditioned using a forward-planned intensity modulated total body irradiation technique

Total body irradiation (TBI) combined with myeloablative chemotherapy has an established role in conditioning for allogeneic haemopoetic stem cell transplant (HSCT) in the treatment of high risk haematological malignancies. TBI is highly immunosuppressant minimising risk of graft rejection, has high anti-tumour efficacy and is effective at penetrating into sanctuary sites meaning it is commonly used in conditioning high risk patients [1,2]. Furthermore, any chemotherapy resistant malignant cells may still be susceptible to radiation.

https://www.thegreenjournal.com/article/S0167-8140(21)06083-7/fulltext?rss=yes

Source: Radiotherapy and Oncology - February 23, 2021 Category: Radiology Authors: E. Durie, E. Nicholson, C. Anthias, E.M. Dunne, M. Potter, M. Ethell, C. Messiou, J. Brennan, S. Eagle, J. Talbot, G. Smyth, W. Ingram, F. Saran, H. Mandeville Tags: Guidelines Source Type: research