Chronic Heartburn Raises Odds for Cancers of Larynx, Esophagus
MONDAY, Feb. 22, 2021 -- People with chronic heartburn may face increased risks of several rare types of cancer, a large U.S. government study shows. Researchers found that among more than 490,000 Americans aged 50 and up, those with...
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Title: Chronic Heartburn Raises Odds for Cancers of Larynx, EsophagusCategory: Health NewsCreated: 2/22/2021 12:00:00 AMLast Editorial Review: 2/23/2021 12:00:00 AM
Researchers found that those with gastroesophageal reflux disease (GERD) had about twice the risk of developing cancers of the esophagus or larynx.
(Wiley) Results from a large prospective study indicate that gastroesophageal reflux disease (GERD), which also causes heartburn symptoms, is linked with higher risks of various cancers of the larynx (or voice box) and esophagus. The study is published early online in CANCER, a peer-reviewed journal of the American Cancer Society.
Conclusion Hyperexcitability of T5 and T6 sympathetic preganglionic fibers appears to be the main etiology of LPR. SNEPI can reduce LES relaxation and improve blood flow to the mucosa, thereby increasing the stability of the vagus reflex and laryngopharyngeal mucosal defense factors. To the best of our knowledge, this case represents the first report of a patient with LPR refractory to PPIs who was successfully treated with SNEPI alone. SNEPI can be considered as an alternative to anti-reflux procedures. References 1. Vakil N, van Zanten SV, Kahrilas P, et al. Global Consensus Group. The Montreal definition and classificat...