PTSD Brain Transcriptomics: Convergent Genomic Signatures Across Biological Sex

While a definitive understanding of the molecular pathology of PTSD is far from current reality, it has become increasingly clear that many of the molecular effects of PTSD are sex-specific. Woman are twice as likely as men to develop PTSD after a traumatic event and neurobiological evidence suggest structural differences between the brains of males versus females with PTSD. Recent advances in genomic technologies have begun to shed light on the sex-specific molecular determinants of PTSD which seem to be governed predominantly by dysfunction of GABAergic signaling and immune function.
Source: Biological Psychiatry - Category: Psychiatry Authors: Tags: Review Source Type: research