ApoA-I mimetics improve aortic stenosis-associated left-ventricular diastolic dysfunction but fail to benefit rabbit models with normal aortic valves

Left-ventricular diastolic dysfunction (LVDD) affects about one quarter of the general population and its prevalence is expected to further increase owing to population ageing [1]. Besides coronary artery disease and arterial hypertension, aortic valve stenosis (AVS) represents a major driver of LVDD. Indeed, the elevated left-ventricular (LV) pressure imposed by the narrowed valve orifice produces interstitial fibrosis which hampers normal diastolic function, leading to overt heart failure and ultimately premature death.
Source: International Journal of Cardiology - Category: Cardiology Authors: Tags: Editorial Source Type: research