Kynurenine 3-monooxygenase deficiency induces depression-like behavior via enhanced antagonism of α7 nicotinic acetylcholine receptors by kynurenic acid.

In conclusion, elevation of KA levels contributes to depression-like behaviors in KMO KO mice by α7nAChR antagonism. The ameliorating effects of nicotine and galantamine on depression-like behaviors in KMO KO mice are associated with the activation of α7nAChR.
PMID: 33607168 [PubMed - as supplied by publisher]

Source: Behavioural Brain Research - February 16, 2021 Category: Neurology Authors: Mori Y, Mouri A, Kunisawa K, Hirakawa M, Kubota H, Kosuge A, Niijima M, Hasegawa M, Kurahashi H, Murakami R, Hoshi M, Nakano T, Fujigaki S, Fujigaki H, Yamamoto Y, Nabeshima T, Saito K Tags: Behav Brain Res Source Type: research