Resting-state hippocampal networks related to language processing reveal unique patterns in temporal lobe epilepsy.

Resting-state hippocampal networks related to language processing reveal unique patterns in temporal lobe epilepsy.
Epilepsy Behav. 2021 Feb 17;117:107834
Authors: Whitten A, Jacobs ML, Englot DJ, Rogers BP, Levine KK, González HFJ, Morgan VL
Abstract
OBJECTIVE: Patients with temporal lobe epilepsy (TLE) commonly experience a broad range of language impairments. These deficits are thought to arise from repeated seizure activity that damages language regions. However, connectivity between the seizure onset region in the hippocampus and regions related to language processing has rarely been studied, and could also have a strong impact on language function. The purpose of this study was to use resting-state functional connectivity (FC) measures to assess hippocampal network patterns and their relation to language abilities in patients with right TLE (RLTE), left TLE (LTLE), and healthy controls.
METHODS: Presurgical resting-state 3T functional MRI data were acquired from 40 patients with mesial TLE (27 RTLE, 13 LTLE) and 54 controls. The regions of interest were the anterior and posterior bilateral hippocampi and eleven regions grouped by frontal or temporo-parietal locations, including large areas of language-related cortex. FC values were computed with the right/left anterior and posterior hippocampi as the seeds and frontal and temporo-parietal regions as targets. Resting-state lateralization indices were also calculated (LI...

Source: Epilepsy and Behaviour - February 17, 2021 Category: Neurology Authors: Whitten A, Jacobs ML, Englot DJ, Rogers BP, Levine KK, González HFJ, Morgan VL Tags: Epilepsy Behav Source Type: research