Recent advances in surgery and its perioperative treatment in people with hemophilia.

Recent advances in surgery and its perioperative treatment in people with hemophilia. Expert Rev Hematol. 2021 Feb 19;: Authors: Rodríguez-Merchán EC Abstract INTRODUCTION: People with hemophilia (PWH) may require some surgical procedures (orthopedic surgery, cardiac surgery, neurosurgery, et cetera) throughout their lives. AREAS COVERED: Articles on surgery and hemophilia published during the year 2020 were analyzed. The principal inclusion factor was a focal point on surgery in hemophilia. Articles that did not concentrate on this subject were not included. EXPERT OPINION: Turoctocog alfa pegol appears to be efficacious for perioperative hemostatic treatment of all kind of surgical operations (minor and major) in PWH A. Long-acting recombinant coagulation factor IX (FIX) albumin fusion protein (rIX-FP) seems to facilitate perioperative management in PWH B. In people suffering from von Willebrand disease (VWD), the utilization of concentrates of von Willebrand factor (VWF) is commonly used for the decrease of exaggerated bleeding during surgical operations. On-demand management with 30-60 IU/kg may keep hemostasis under control during all kind of surgical operations. Factor concentrates with extended half-life (EHL) are a good option to standard half-life (SHL) products in PWH undergoing surgery, permitting diminished number of infusions and inferior consuming, particularly for EHL FIX. Supplementary factor VIII (F...
Source: Expert Review of Hematology - Category: Hematology Tags: Expert Rev Hematol Source Type: research