Relation of Decongestion and Time to Diuretics to Biomarker Changes and Outcomes in Acute Heart Failure

In patients with acute heart failure (AHF), prompt initiation of decongestive therapy may help mitigate the adverse effects of congestion and multi-organ injury in the early phase of hospitalization and result in improved outcomes. Several studies have examined the relationship between early initiation of diuretics and/or vasoactive agents and clinical outcomes 1-4. However, a pathophysiologic link between early treatment, decongestion, organ damage and clinical outcomes has not been fully assessed, especially from the viewpoint of biomarker trajectories.

Source: The American Journal of Cardiology - February 19, 2021 Category: Cardiology Authors: Yu Horiuchi, Nicholas Wettersten, Dirk J. van Veldhuisen, Christian Mueller, Gerasimos Filippatos, Richard Nowak, Christopher Hogan, Michael C. Kontos, Chad M. Cannon, Gerhard A. M üeller, Robert Birkhahn, Pam Taub, Gary M. Vilke, Olga Barnett, Kenneth M Source Type: research