Withdrawal of dornase alfa increases ventilation inhomogeneity in children with cystic fibrosis

The lung clearance index (LCI) measured by multiple breath washout (MBW) is a sensitive marker of lung disease even early in life in patients with cystic fibrosis (CF) [1 –3]. Conventionally, pulmonary function in patients with CF is monitored by spirometry from school-age, using the forced expired volume in 1 second (FEV1) as primary outcome [4]. Due to advancements in clinical care, an increasing proportion of school-age children with CF have retained FEV1 withi n the normal or near-normal range over the last decades [5].
Source: Journal of Cystic Fibrosis - Category: Respiratory Medicine Authors: Tags: Original Article Source Type: research