Efficacy of a nitroglycerin-citrate-ethanol lock solution in maintaining central venous catheter patency and preventing thrombotic occlusions in cancer patients

Indwelling central venous catheters (CVCs) provide life-sustaining vascular access in severely ill patients, such as those with cancer. Nonetheless, they are susceptible to microbial colonization and loss of patency due to luminal occlusion. The most commonly reported causes of CVC malfunction are patency failure (PF) and CVC-associated infections [1]. The loss of catheter patency, which can lead to the inability to use one or more of the lumina for treatment, can develop via three different mechanisms: thrombosis, mechanical obstruction, and chemical buildup of precipitates on the catheter walls.

Source: Thrombosis Research - February 19, 2021 Category: Hematology Authors: Khalil Melissa, Chaftari Anne Marie, Dagher Hiba, Rosenblatt Joel, Jiang Ying, A. Reitzel Ruth, Hachem Ray, Hirsh-Ginsberg Cheryl, Raad I. Issam Tags: Letter to the Editors-in-Chief Source Type: research