Boosting Room Temperature Phosphorescence Performance by Alkyl Modification for Intravital Orthotopic Lung Tumor Imaging

In this study, a series of keto derivatives with efficient RTP in crystals are developed through the regulation of molecular aggregation states by simple alkyl groups, resulting in impressive luminescence performance with a longer lifetime and higher efficiency of up to 868  ms and 51.59%, respectively. All the alkyl‐substituted derivatives exhibit bright RTP intensities after heavy grinding with a pestle, indicating their robust RTP features, which are suitable for many fields. Encouraged by the excellent RTP performance of these luminogens in the crystalline state , successful orthotopic lung tumor imaging with a high signal‐to‐background ratio (SBR) of 65 is demonstrated in this study to provide the promise of pure organic RTP materials for disease diagnosis, which hold the advantages of low autofluorescence interference and high signal‐to‐background ratio.

Source: Small - February 18, 2021 Category: Nanotechnology Authors: Heqi Gao, Zhiyuan Gao, Di Jiao, Jingtian Zhang, Xiaolin Li, Qiyun Tang, Yang Shi, Dan Ding Tags: Full Paper Source Type: research