Adding Toxicological Context to Nanotoxicity Study Reporting Using the NanoTox Metadata List

The novelty in the proposed nanotoxicity reporting checklist is a modular approach in selecting reporting standards for nanomaterial toxicity studies where the three components need to be covered: material characteristics, experimental set ‐up/biological test system description, and toxicological context. It is designed to allow for nanomaterials toxicity data and knowledge integration, reuse, and cross‐disciplinary communication. AbstractThis paper proposes a list of specifications (NanoTox metadata list) to be reported about nanotoxicity experiments (metadata) together with resultant data to add toxicological context to reported studies. In areas involving nanomaterials (NMs), existing metadata reporting standards include the reporting of experimental conditions and protocols (MIRIBEL) and material characteristics (MINChar and MIAN), as well as reporting focused on specific experiments (MINBE). NanoCRED is a similarly transparent and structured framework, however, it is developed to guide risk assessors in evaluating the reliability and relevance of NM ecotoxicity studies. There is no reporting standard which would include interpretation of the aims and outcomes of nanotoxicity studies beyond regulatory purposes. The proposed NanoTox metadata reporting checklist is elaborated to extend reporting toward describing nanotoxicological context and thus is a logical complement to technology/material ‐assay focused reporting checklists. It is further designed to allow for NM...
Source: Small - Category: Nanotechnology Authors: Tags: Concept Source Type: research