Loss of CASK Accelerates Heart Failure Development.

Conclusions: CASK associates with CaMKII in the human heart. CASK-KO in mice increases CaMKII activity, leading to contractile dysfunction and arrhythmias. Increasing CASK expression reduces CaMKII activity, improves Ca handling and contractile function. PMID: 33593074 [PubMed - as supplied by publisher]

https://www.ncbi.nlm.nih.gov/pubmed/33593074?dopt=Abstract

Source: Circulation Research - February 17, 2021 Category: Cardiology Authors: Mustroph J, Sag CM, Bähr F, Schmidtmann AL, Gupta SN, Dietz A, Islam MT, Lücht CM, Beuthner BE, Pabel S, Baier MJ, El-Armouche A, Sossalla S, Anderson ME, Möllmann J, Lehrke M, Marx N, Mohler PJ, Bers DM, Unsöld B, He T, Dewenter M, Backs J, Maier LS, Tags: Circ Res Source Type: research