Vision loss following high-dose proton-based radiotherapy for skull-base chordoma and chondrosarcoma

Chordomas and chondrosarcomas arising in the skull base often present a treatment challenge given their close proximity to critical neurovascular structures. Although primary management involves maximal safe resection, the addition of radiotherapy (RT) demonstrably increases local control [1,2]. Furthermore, dose-escalated and proton-based RT have been associated with both a local control and an overall survival benefit [3 –5]. Therefore, highly conformal RT, such as stereotactic radiosurgery, proton therapy, or intensity-modulated radiotherapy, are the prevailing techniques to deliver sufficient radiation dose to the tumor without exceeding dosimetric constraints to organs at risk (OARs).
Source: Radiotherapy and Oncology - Category: Radiology Authors: Tags: Original Article Source Type: research