Vision loss following high-dose proton-based radiotherapy for skull-base chordoma and chondrosarcoma
Chordomas and chondrosarcomas arising in the skull base often present a treatment challenge given their close proximity to critical neurovascular structures. Although primary management involves maximal safe resection, the addition of radiotherapy (RT) demonstrably increases local control [1,2]. Furthermore, dose-escalated and proton-based RT have been associated with both a local control and an overall survival benefit [3 –5]. Therefore, highly conformal RT, such as stereotactic radiosurgery, proton therapy, or intensity-modulated radiotherapy, are the prevailing techniques to deliver sufficient radiation dose to the tumor without exceeding dosimetric constraints to organs at risk (OARs).
Source: Radiotherapy and Oncology - Category: Radiology Authors: Alexandra N. De Leo, Adam L. Holtzman, M.W. Ho, Christopher G. Morris, Michael S. Rutenberg, Ronny L. Rotondo, James E. Bates, Daniel J. Indelicato, Dinesh Rao, Mohammad ASA Hasan, William M. Mendenhall Tags: Original Article Source Type: research
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