MicroRNA Biophysically Modulates Cardiac Action Potential via Directly Binding to Ion Channel.

Conclusions: Our study reveals a novel evolutionarily-conserved biophysical action of endogenous miRs in modulating cardiac electrophysiology. Our discovery of miRs' biophysical modulation provides a more comprehensive understanding of ion-channel dysregulation and may provide new insights into the pathogenesis of cardiac arrhythmias. PMID: 33590773 [PubMed - as supplied by publisher]

https://www.ncbi.nlm.nih.gov/pubmed/33590773?dopt=Abstract

Source: Circulation - February 16, 2021 Category: Cardiology Authors: Yang D, Wan X, Dennis AT, Bektik E, Wang Z, Costa MGS, Fagnen C, Vénien-Bryan C, Xu X, Gratz DH, Hund TJ, Mohler PJ, Laurita KR, Deschênes I, Fu JD Tags: Circulation Source Type: research