Effects of handling on the behavioural phenotype of the neuregulin 1 type III transgenic mouse model for schizophrenia.
In conclusion, handling methods have a significant impact on a variety of behavioural domains thus the impact of routine handling procedures need be considered when testing behavioural phenotypes. Handling did not change the main schizophrenia-relevant characteristics of Nrg1 III tg mice but affected the acoustic startle-response in a genotype- and sex-specific manner. Future research should evaluate the effect of handling on other genetic models.
PMID: 33588020 [PubMed - as supplied by publisher]
Source: Behavioural Brain Research - Category: Neurology Authors: Guerra S, Chesworth R, Weickert CS, Karl T Tags: Behav Brain Res Source Type: research
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