Prognostic factors of Colorectal Cancer patients with Brain Metastases

The incidence of brain metastases (BM) from colorectal cancer (CRC) ranges from 0.6 to 3.2% of all CRC and is increasing [1 –4]. Improvements in the treatment of metastatic CRC (mCRC) with prolonged survival of more than 30 months probably explain this phenomenon as it corresponds to the mean interval between primary tumor and BM diagnosis [4,5]. Few small series of patients with BM from CRC have identified a specific profile of these patients having predominant primary tumor site in the rectum and sigmoid colon, frequent lung metastases and high rate of KRAS-mutated tumors [2,4,6–8].

Source: Radiotherapy and Oncology - February 15, 2021 Category: Radiology Authors: Pauline Roussille, Marie Auvray, Damien Vansteene, Thierry Lecomte, Eug énie Rigault, Marianne Maillet, Christophe Locher, Marie Dior, Vincent Hautefeuille, Pascal Artru, May Mabro, Yann Touchefeu, Lysiane Marthey, Valérie Moulin, Samy Louafi, Cédric L Tags: Original Article Source Type: research