Chenopodium quinoa ethanolic extract ameliorates cyclophosphamide ®-induced hepatotoxicity in male rats

This study aimed to investigate ameliorative effect ofChenopodium quinoa ethanolic extract (QEE) against cyclophosphamide ®-induced hepatotoxicity. Four groups (10 male Wistar rats each) were used: (1) healthy control group; (2) rats treated orally with QEE (400 mg/kg/day) for 4 weeks; (3) rats injected intraperitoneally with cyclophosphamide® (150 mg/kg/week) for 4 weeks; (4) rats received QEE after cyclophosphamide ® intoxication another 4 weeks. The results revealed that QEE succeeded to decrease the hepatotoxicity-induced by cyclophosphamide®; this was evidenced by the significant reduction in serum ALAT, ASAT, GGT, ALP, total cholesterol, triglycerides, LDL-cholesterol, and TNF-α IL 1β and IL6, as well as hepatic MDA, nitric oxide levels, and DNA fragmentation coupled with a marked rise in serum albumin and HDL-cholesterol level as well as hepatic GSH, SOD, GPx, and catalase values. QEE succeeded also in improving the histopathological picture of the liver. It could be concluded that QEE succeeded , to a great extent, to counteract the oxidative stress and regenerated the liver against cyclophosphamide®-resultant hepatotoxicity. QEE could be considered a promising candidate as a food supplement for the protection against the side effects of cyclophosphamide®.
Source: Comparative Clinical Pathology - Category: Pathology Source Type: research