Two faces of RUNX3 in myeloid transformation

RUNX transcription factors are critical for development and normal tissue homeostasis and have been characterized as oncogenes or tumor suppressors in the pathogenesis of various tumors 1,2. RUNX family members, including RUNX1, RUNX2, and RUNX3, are highly conserved in the runt domain, which binds to the consensus DNA sequence and is involved in dimerization with the common co-factor CBF β. Loss-of-function mutations in and the deletion of RUNX1 are frequently observed in myeloid malignancies, including myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML) 3,4.
Source: Experimental Hematology - Category: Hematology Authors: Tags: Review Source Type: research