Hypermethylation of Mitochondrial Cytochrome b and Cytochrome c Oxidase II Genes with Decreased Mitochondrial DNA Copy Numbers in the APP/PS1 Transgenic Mouse Model of Alzheimer's Disease.
We examined mtDNA copy numbers and the levels of expression by quantitative real-time PCR. Average methylation levels of different CpG sites were ≤ 4.0%. Methylated mtDNA accounted for only a small part of the total mtDNA. We also observed hypermethylation of mitochondrial CYTB and COX II genes with decreased mtDNA copy numbers and expression in the hippocampi of APP/PS1 transgenic mice. mtDNA methylation may play an important role in AD pathology, which may open a new window for AD therapy.
PMID: 33580369 [PubMed - as supplied by publisher]
Source: Neurochemical Research - Category: Neuroscience Authors: Xu Y, Cheng L, Sun J, Li F, Liu X, Wei Y, Han M, Zhu Z, Bi J, Lai C, Wang Y Tags: Neurochem Res Source Type: research
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