Auditory environmental enrichment prevents anxiety-like behavior, but not cortisol responses, evoked by 24-h social isolation.

Auditory environmental enrichment prevents anxiety-like behavior, but not cortisol responses, evoked by 24-h social isolation.
Behav Brain Res. 2021 Feb 09;:113169
Authors: Marchetto L, Barcellos LJG, Koakoski G, Soares SM, Pompermaier A, Maffi VC, Costa R, da Silva CG, Zorzi NR, Demin KA, Kalueff AV, de Alcantara Barcellos HH
Abstract
The zebrafish (Danio rerio) is widely used as a promising translational model organism for studying various brain disorders. Zebrafish are also commonly used in behavioral and drug screening assays utilizing individually tested (socially isolated) fish. Various sounds emerge as important exogenous factors that may affect fish behavior. Mounting evidence shows that musical/auditory environmental enrichment can improve welfare of laboratory animals, including fishes. Here, we show that auditory environmental enrichment mitigates anxiogenic-like effects caused by acute social isolation in adult zebrafish. Thus, auditory environmental enrichment may offer an inexpensive, feasible and simple tool to improve welfare of zebrafish stocks in laboratory facilities, reduce unwanted procedural stress, lower non-specific behavioral variance and, hence, collectively improve zebrafish data reliability and reproducibility.
PMID: 33577884 [PubMed - as supplied by publisher]

Source: Behavioural Brain Research - February 9, 2021 Category: Neurology Authors: Marchetto L, Barcellos LJG, Koakoski G, Soares SM, Pompermaier A, Maffi VC, Costa R, da Silva CG, Zorzi NR, Demin KA, Kalueff AV, de Alcantara Barcellos HH Tags: Behav Brain Res Source Type: research