Evaluation of Interim MRI Changes During Limited-Field Radiation Therapy for Glioblastoma and Implications for Treatment Planning

Glioblastoma (GBM) is the most common primary malignant brain tumor in adults and is treated with a combination of surgery, focal radiation therapy (RT), and temozolomide (TMZ) [1]. RT volume definitions gradually emerged based on surgical series demonstrating that 80-90% of recurrences occurred within 2 cm of the enhancing tumor on CT or MRI and that isolated tumor cells were present at the periphery of T2 abnormalities [2 –5]. A landmark surgical study demonstrated that the T1 contrast-enhancing abnormality contained high-density GBM tumor cells, while the T2 abnormality represented either brain parenchyma with infiltrating tumor cells or peritumoral edema [3].

Source: Radiotherapy and Oncology - February 12, 2021 Category: Radiology Authors: Comron Hassanzadeh, Soumon Rudra, Sirui Ma, Randall Brenneman, Yi Huang, Lauren Henke, Christopher Abraham, Jian Campian, Christina Tsien, Jiayi Huang Tags: Original Article Source Type: research