Advances in medical therapy for glaucoma
Purpose of review To discuss a new class of medication that has recently become available for the treatment of glaucoma; as well as share insights into developments in glaucoma medicine administration which has the potential to revolutionize medical therapy for glaucoma. Recent findings Newly available eye drops, netarsudil 0.02% and latanoprostene bunod 0.024%, are improving aqueous outflow through the conventional outflow tract. Other new developments in medical glaucoma are focused on alternative methods for sustained glaucoma medication delivery. Summary Newer medications may be able to extend the duration of medically controlled glaucoma, delaying or possibly eliminating the need of glaucoma surgery for some patients. Alternative methods of delivery for glaucoma medications may be a key factor in improving outcomes with currently available medications.
In conclusion SNP rs112369934 may play a role in POAG pathogenesis in male AA individuals. However, this SNP has been implicated in higher POAG risk in both male and female AA POAG cases.
Juvenile-onset open-angle glaucoma (JOAG) is a subset of primary open-angle glaucoma that is diagnosed before 40 years of age. The disease may be familial or non-familial, with proportions varying among different populations. Myocilin mutations are the most commonly associated. JOAG is characterized by high intraocular pressures (IOP), with many patients needing surgery. The mean age at diagnosis is in the 3rd decade, with a male preponderance. Myopia is a common association. The pathophysiology underlying the disease is immaturity of the conventional outflow pathways, which may or may not be observed on gonioscopy and ant...
Eye, Published online: 15 September 2021; doi:10.1038/s41433-021-01734-4Endocyclophotocoagulation combined with phacoemulsification in surgically naive primary open-angle glaucoma: three-year results
Conditions: Glaucoma, Open-Angle; Ocular Hypertension Intervention: Device: DSLT Sponsor: Belkin Laser Ltd. Not yet recruiting
CONCLUSIONS: AMD, cataract and DRED but not glaucoma are associated with an increased risk of dementia. Individuals with both ophthalmic and systemic conditions are at higher risk of dementia compared with those with an ophthalmic or systemic condition only.PMID:34518160 | DOI:10.1136/bjophthalmol-2021-319508
Conditions: Non-infectious Anterior Uveitis; Uveitic Glaucoma Interventions: Drug: TRS01; Drug: FDA approved steroid eye drop Sponsor: Tarsier Pharma Not yet recruiting
In this study, we established a mouse model of repeated transient Spike IOP to investigate the direct damage to the retina following Spike IOP attacks, and elucidated the underlying molecular mechanism. We analyzed the changes in the number of retinal ganglion cells (RGCs) via immunofluorescence. Thereafter, we detected retinal cell apoptosis via terminal deoxynucleotidyl transferase deoxyuridine triphosphate (dUTP) nick-end labeling (TUNEL) staining, and performed RNA sequencing (RNA-seq) to reveal the underlying molecular mechanism. Finally, we validated the expression of key molecules in the endoplasmic reticulum (ER) s...
rasov Monogenic syndromic disorders frequently feature ocular manifestations, one of which is glaucoma. In many cases, glaucoma in children may go undetected, especially in those that have other severe systemic conditions that affect other parts of the eye and the body. Similarly, glaucoma may be the first presenting sign of a systemic syndrome. Awareness of syndromes associated with glaucoma is thus critical both for medical geneticists and ophthalmologists. In this review, we highlight six categories of disorders that feature glaucoma and other ocular or systemic manifestations: anterior segment dysgenesis syndromes,...
Worldwide, the prevalence of type 2 diabetes is increasing due to an aging population and increasing obesity levels . As a consequence, it is estimated that the prevalence of diabetic retinopathy, a common microvascular complication of diabetes , will grow from 126.6 million in 2011 to 191.0 million by 2030 [3,4]. Diabetic retinopathy can cause vision problems including vitreous haemorrhage, retinal detachment, glaucoma and blindness . Regular diabetic retinopathy screening leads to the earlier detection of retinopathy and treatment that can prevent or delay the development of diabetes-related blindness .