Reply: Tissue-resident CD8+ memory T cells in multiple sclerosis

We thankHohlfieldet al. (2020) for their appreciation and discussion of our work. Our data provide an extension of the data earlier reported byMachado-Santoset al. (2018). We showed that white matter perivascular CD8+ T cells of multiple sclerosis donors co-expressed CD69 with variable levels of CD103 and CD49a, PD-1, and CXCR6 (Fransenet al., 2020), characterizing them as tissue-resident memory T (TRM) cells (Kumaret al., 2017).
Source: Brain - Category: Neurology Source Type: research