Case Report: Borrelia-DNA Revealed the Cause of Arthritis and Dermatitis During Treatment With Rituximab
Borrelia-specific antibodies in serum did not contribute to the diagnosis of Borrelia arthritis or Borrelia-associated dermatitis in a young woman with ongoing treatment with rituximab due to multiple sclerosis. The diagnosis was confirmed by the detection of Borrelia-DNA in a skin punch biopsy. The patient history did not reveal any tick exposure. She had suffered for several months from fluctuating pain and swelling of the right knee as well as skin involvement with redness and oedema around the ankle of the same leg. Monoarthritis was confirmed by a rheumatologist. Knee puncture was performed but the synovial fluid was only sufficient for microscopic examination of crystals. Neither monosodium urate crystals nor calcium pyrophosphate crystals were found. Borrelia serology in blood revealed borderline levels of immunoglobulin (Ig)M and IgG, respectively. Treatment with doxycycline resulted in resolution of the joint and skin manifestations within a month. This case highlights that Borrelia-specific antibody levels cannot be reliably interpreted in patients who have received B-cell depleting therapy. Under these circumstances, detection of the bacterial genome in different body fluids, such as in the skin, can be a useful complement to the diagnosis of Lyme disease. In this young female, the diagnosis would certainly have been further delayed without the detection of Borrelia-DNA in the skin.
In this study, atomistic structure models derived from tobermorite were combined with a supercell approach using TOPAS. By accounting for nanostructural features such as isolated layers, turbostratic disorder and, for the first time, fibrils, characteristic reflections and asymmetric bands were more accurately simulated than before, providing the means for phase quantification and refinement of structural sites. This improved methodology is applied to autoclaved aerated concrete and the experimental study of related hydrothermal reactions. Scanning electron microscopy indicated a fibrillar morphology for intermediate C-(A)...
AbstractLight management affects the health outcomes and growth performance of broiler chickens. However, the effects of different light intensities on growth performance and its association with tibia development of broilers remain unclear. In the present study, 462 Ross male broilers were divided into seven treatment groups with 6 replicates (11 birds per replicate), and then were subjected to different light intensity levels (0.5, 2, 5, 7, 9, 13 or 19 Lx) for 42 days. The results demonstrated that broilers under lower light intensity (2, 5Lx) obtained higher body weight (p
A study found robust links between subjective fatigue and depression in early relapsing-remitting multiple sclerosis.First Look
AbstractThe aim of the study was to investigate the epidemiological characteristics of stone components in patients with urolithiasis and analyze the associations between stone components with patients' clinical characteristics. A total of 7126 patients with urolithiasis between July 2005 and June 2020 were retrospectively analyzed. In this research, calcium oxalate stones (74.6%) accounted for the highest proportion, followed by infection stones (11.8%), uric acid (10.6%), brushite (2.0%), and others (1.1%). The change in trend in the composition of urinary stones revealed that the proportion of uric acid declined steadil...
ConclusionsIn this updated systematic review and meta-analysis, uterine exteriorization was associated with an increased risk of IONV but no significant change in perioperative hemoglobin decrease compared within situ repair.Study registrationPROSPERO (CRD42020190074); registered 5 July 2020.
ConclusionsGiven the perceived benefits of regional over general anesthesia, approximately half of the members of three regional anesthesia societies seem to have expanded their use of regional anesthesia techniques during the initial surge of the COVID-19 pandemic.
Listen to an audio podcast of the January 12, 2022, FDA Drug Safety Communication warning that dental problems have been reported with medicines containing buprenorphine that are dissolved in the mouth.
Condition: Salivary Calcium Intervention: Other: Saliva Sponsor: Ajman University Completed
Condition: Low Back Pain Interventions: Drug: 380 mg/300 mg comprimidos metocarbamol/paracetamol - 4 times daily; Drug: 380 mg/300 mg comprimidos metocarbamol/paracetamol - 6 times daily Sponsors: Aziende Chimiche Riunite Angelini Francesco S.p.A; Hippocrates Research Recruiting
Conditions: Opioid Use Disorder; Chronic Pain Intervention: Behavioral: CBT4CBT COPES Sponsors: Yale University; National Institutes of Health (NIH) Not yet recruiting