Distinct effects of chondroitin sulfate on hematopoietic cells and the stromal microenvironment in bone marrow hematopoiesis

In bone marrow (BM) hematopoiesis, it is well known that self-renewal, proliferation, and differentiation of hematopoietic stem and progenitor cells (HSPCs) are regulated by the microenvironment called the BM niche, which is affected by the interactions between hematopoietic cells and stromal cells. The BM niche mainly consists of two anatomically distinct cellular entities, the “endosteal niche” and the “vascular niche”. HSPCs can move through these two regions and interact with the extracellular matrix (ECM) components.

Source: Experimental Hematology - February 11, 2021 Category: Hematology Authors: Takayuki Katagiri, Shun Uemura, Takashi Ushiki, Yaeko Nakajima-Takagi, Motohiko Oshima, Tadahisa Mikami, Asami Kawasaki, Hajime Ishiguro, Tomoyuki Tanaka, Hirohito Sone, Hiroshi Kitagawa, Michihiro Igarashi, Atsushi Iwama, Masayoshi Masuko Source Type: research