Impact of Cell of Origin Classification on Survival Outcomes After Autologous Transplantation in Relapsed/refractory Diffuse Large B-cell Lymphoma

Diffuse large B-cell lymphoma (DLBCL) is the most common type of non-Hodgkin lymphoma worldwide with distinct biological and clinical heterogeneity. Gene-expression profiling (GEP) has allowed DLBCL to be classified into two molecular prognostic subgroups: germinal center B-cell like (GCB) and activated B-cell like (ABC), based on cell of origin (COO) [1]. In clinical practice, GEP has been replaced by the more readily available immunohistochemistry (IHC). Using an IHC panel composed of CD10, BCL6 and MUM1, the Hans algorithm was developed to classify DLBCL into GCB and non-GCB subtypes [2, 3].

Source: Biology of Blood and Marrow Transplantation - February 11, 2021 Category: Hematology Authors: Jacinth Joseph, Fady Hennawy, Mustafa Nooruldeen Abdulrazzaq, Neeraj Saini, Junsheng Ma, Romil D. Patel, Chitra M. Hosing, Amin M. Alousi, Paolo Anderlini, Uday R. Popat, Muzaffar H. Qazilbash, Elizabeth J. Shpall, Samer Srour, Partow Kebriaei, Qaiser Bas Source Type: research