Illuminate TWEAK/Fn14 pathway in intrahepatic cholangiocarcinoma: Another brick in the wall of tumor niche

More than 20 years ago, a new secreted ligand of the tumor necrosis factor (TNF) family was identified in mouse peritoneal macrophages, human tonsils and fetal liver. However, in contrast to TNF, TWEAK induced only slightly apoptosis in a panel of cell types including hematopoietic cells, fibroblasts and cancer cells, and was thus named TWEAK for “Tumor necrosis factor-like WEAK inducer of apoptosis”. There are 2 forms of TWEAK, a membrane-bound and a soluble form. Like TNF, TWEAK activates the NF-κB pathway and thereby inflammatory responses.

Source: Journal of Hepatology - February 11, 2021 Category: Gastroenterology Authors: Luca Fabris, Massimiliano Cadamuro, Laura Fouassier Tags: Editorial Source Type: research