Helical Antimicrobial Peptide Foldamers Containing Non-proteinogenic Amino Acids.

Helical Antimicrobial Peptide Foldamers Containing Non-proteinogenic Amino Acids.
ChemMedChem. 2021 Feb 10;:
Authors: Yokoo H, Hirano M, Misawa T, Demizu Y
Abstract
Antimicrobial peptides (AMPs) are potential novel therapeutic drugs against microbial infections. Most AMPs function by disrupting microbial membranes because of their amphipathic properties and ordered secondary structures. In this minireview, we describe recent efforts to develop helical AMP foldamers containing non-proteinogenic amino acids, such as α,α-disubstituted α-amino acids, β-amino acids, γ-amino acids, side-chain stapling and N-alkyl glycines.
PMID: 33565721 [PubMed - as supplied by publisher]

Source: ChemMedChem - February 10, 2021 Category: Chemistry Authors: Yokoo H, Hirano M, Misawa T, Demizu Y Tags: ChemMedChem Source Type: research