Glaucoma and neuroinflammation: an overview

Glaucoma is an optic neuropathy characterized by well-defined optic disc morphological changes (i.e. cup enlargement, neuroretinal border thinning, and notching, papillary vessel modifications) consequent to retinal ganglion cell loss, axonal degeneration, and lamina cribrosa remodeling. These modifications tend to be progressive and are the main cause of functional damage in glaucoma. Despite the latest findings about the pathophysiology of the disease, the exact trigger mechanisms, and the mechanism of degeneration of retinal ganglion cells and their axons have not been completely elucidated.
Source: Survey of Ophthalmology - Category: Opthalmology Authors: Source Type: research