Vinexin-{beta} Exacerbates Cardiac Dysfunction Post-Myocardial Infarction via Mediating Apoptotic and Inflammatory Responses

In this study, dramatically upregulated Vinexin-β expressions were observed in both the ischemic human hearts and infarcted animal hearts. To further explore the potential involvement of Vinexin-β in MI, we induced MI injury in global Vinexin-β knockout (KO) mice and wild-type (WT) controls as well as mice with cardiac-specific overexpression of the human Vinexin-β gene (TG) and non-transgenic (NTG) littermates. Compared with that observed in WT controls, Vinexin-β deficiency significantly decreased MI-induced infarct size, concomitant with an improvement in cardiac function, leading to an increase in the survival rate. The myocardial apoptosis in the border zone was dramatically reduced by Vinexin-β deficiency, resulting from the altered expression of apoptotic factors. Furthermore, Vinexin-β depletion mitigated the inflammatory response, as evidenced by reduced inflammatory cell infiltration, decreased expression of cytokines, and the inactivation of NF-κB signalling. In contrast, Vinexin-β-TG mice were much more susceptible to MI injury compared with NTG controls. Further mechanism analyses suggested that Vinexin-β exerted detrimental effects largely dependent on blocking AKT signalling. The effects and mechanisms of Vinexin-β on MI observed in vivo were further confirmed by our in vitro assays.Correctively, these data demonstrate for the first time that Vinexin-β increases MI-induced mortality and worsens cardia...
Source: Clinical Science - Category: Biomedical Science Authors: Source Type: research

Related Links:

Background The primary cause of death among African American women older than 50 years is cardiovascular disease. Cardiovascular disease affects more than 16.8 million Americans and occurs when plaque builds up in the arteries that provide blood to the heart. This often leads to a partial or complete blockage, causing a myocardial infarction (heart attack). There is limited research regarding the lived experiences of African American women before and after a myocardial infarction. Objective The purpose of this qualitative study was to explore the experiences of African American women living in the southern region of t...
Source: Journal of Cardiovascular Nursing - Category: Nursing Tags: ARTICLES: Women and Cardiovascular Disease Source Type: research
Authors: Alexopoulos D, Sfantou D, Lianos I, Pappas C, Revela I, Triantafyllidi H, Ikonomidis I Abstract Given that patients with prior myocardial infarction and features of high ischemic and low bleeding risk may benefit by extending dual antiplatelet therapy beyond 1 year, we aimed of assessing platelet reactivity provided by ticagrelor 60 mg bid versus prasugrel 5 mg od in 20 such patients participating in a randomized, crossover study. The primary end point of platelet reactivity at the end of the two treatment periods (by VerifyNow, in PRU) was significantly lower for ticagrelor (31.9 PRU [95% CI 12.3-51.4]) c...
Source: Platelets - Category: Hematology Tags: Platelets Source Type: research
Source: BMJ Comments - Category: General Medicine Source Type: forums
Condition:   Myocardial Infarction Intervention:   Other: exosome Sponsor:   Xinhua Hospital, Shanghai Jiao Tong University School of Medicine Not yet recruiting
Source: - Category: Research Source Type: clinical trials
Louise McGill, 47, from County Durham, noticed the unusual flavour in her wine two years ago after returning from a family day out with her twin daughters.
Source: the Mail online | Health - Category: Consumer Health News Source Type: news
We’re so good at sleeping we can even do it with our eyes shut. Still, there’s always room for improvement. Sleep tracking is a great way to get to know ourselves a bit better and even improve our way of life. It’s expensive and complicated to get a professional sleep analysis but with health gadgets on the rise, we have more and more options to take things in our own hands. SleepOn Go2Sleep promises to help us understand our sleeping patterns better through its ring-shaped sleep tracker. We got curious what it can do, so we tested it for a couple of days. Here’s our comprehensive review. Big ide...
Source: The Medical Futurist - Category: Information Technology Authors: Tags: Health Sensors & Trackers fitness future gadget health trackers personalized personalized health review ring sleep sleep apnea sleep app sleep optimization sleep sensor sleep tracker sleep tracking technology wellbeing Source Type: blogs
T cell autoreactivity is a hallmark of autoimmune diseases but can also benefit self-maintenance and foster tissue repair. Here, we investigated whether heart-specific T cells exert salutary or detrimental effects in the context of myocardial infarction (MI), the leading cause of death worldwide. After screening more than 150 class II–restricted epitopes, we found that myosin heavy chain α (MYHCA) was a dominant cardiac antigen triggering post-MI CD4+ T cell activation in Balb/c mice. Transferred MYHCA614–629-specific CD4+ T cells (TCR-M cells) selectively accumulated in the myocardium and mediastinal lym...
Source: Journal of Clinical Investigation - Category: Biomedical Science Authors: Source Type: research
Cardiac tissue necrosis secondary to coronary artery occlusion is one of the most common and deadly sterile injuries in developed countries. In this issue of the JCI, Rieckmann et al. identified and characterized antigen-specific CD4+ T helper (Th) cells that developed in the context of myocardial infarction (MI) in mice. They showed that myosin heavy chain α (MYHCA) is a dominant cardiac autoantigen and that T cells with T cell receptor (TCR) specificity to MYHCA acquired a Treg phenotype when adoptively transferred into infarcted mice, which mediated a cardioprotective healing response. Thus, Rieckmann et al. showe...
Source: Journal of Clinical Investigation - Category: Biomedical Science Authors: Source Type: research
AbstractCardioprotection aims at infarct size reduction and improvement of clinical outcome from myocardial infarction. The translation of cardioprotection from preclinical and promising proof-of-concept studies to clinical benefit for patients has been largely disappointing. Almost all of these studies which did not translate into clinical benefit had infarct size reduction as the primary endpoint and used protocols selected to achieve infarct size reduction. The present review puts forward the hypothesis that the coronary circulation is a so far neglected target of cardioprotection. Mechanisms of ischemia –reperfus...
Source: Basic Research in Cardiology - Category: Cardiology Source Type: research
Edinburgh University scientists found that when women were assessed with a troponin blood test they were about half as likely as men to receive recommended heart attack treatments.
Source: the Mail online | Health - Category: Consumer Health News Source Type: news
More News: Biomedical Science | Genetics | Heart | Heart Attack | Science | Study