Vortioxetine increases absence-like seizures in WAG/Rij rats but decreases penicillin- and pentylenetetrazole-induced seizures in Wistar rats.

CONCLUSION: The results of this study suggested that vortioxetine has anticonvulsant activity in penicillin- and pentylenetetrazole-induced seizure models. However, it exhibited proconvulsant activity in the absence epileptic WAG/Rij rats. PMID: 33561766 [PubMed - as supplied by publisher]

https://www.ncbi.nlm.nih.gov/pubmed/33561766?dopt=Abstract

Source: Epilepsy and Behaviour - February 5, 2021 Category: Neurology Authors: Aygun H, Ayyildiz M Tags: Epilepsy Behav Source Type: research