Dissecting the Cellular Mechanism of Prostacyclin Analog Iloprost in Reversing Vascular Dysfunction in Scleroderma

ConclusionOur data suggest that the long ‐lasting effects of iloprost reflect its ability to stabilize adherens junctions, resulting in increased tubulogenesis and barrier function and reduced EndoMT. These findings provide a mechanistic basis for the use of iloprost in treating SSc patients with RP and digital ulcers.

Source: Arthritis and Rheumatology - February 8, 2021 Category: Rheumatology Authors: Pei ‐Suen Tsou, Pamela J. Palisoc, Nicholas A. Flavahan, Dinesh Khanna Tags: Full Length Source Type: research