The TNFRSF11B mutation associated with calcium pyrophosphate deposition disease results in ineffective osteoclast suppression

ConclusionsWe show here that OPG ‐XL is a loss‐of‐function mutation as it relates to RANKL‐mediated osteoclastogenesis and thus may permit increased OC number and heightened bone turnover. Further studies will be necessary to demonstrate how this mutation contributes to arthritis in individuals carrying this mutation.

Source: Arthritis and Rheumatology - February 9, 2021 Category: Rheumatology Authors: Elizabeth Mitton ‐Fitzgerald, Claudia M. Gohr, Charlene J Williams, Amaryllis Ortiz, Gabriel Mbalaviele, Ann K. Rosenthal Tags: BRIEF REPORT Source Type: research