Optimized SEEG-guided radiofrequency thermocoagulation in the treatment of pediatric hypothalamic hamartomas

Hypothalamic hamartomas (HHs) are rare congenital malformations [1] that typically manifest as refractory epilepsys [2] with or without central precocious puberty and are located in the region of the tuber cinereum and third ventricles [1]. HHs are non-neoplastic heterotopias that consist of normal neuronal tissues [3]. The estimated incidence of HH is one per 100,000-1,000,000 in the population [4 –5]. In contrast to the hypothesis that epileptogenesis is strictly a cortical phenomenon, depth electrode recordings demonstrated that intrinsic subcortical epileptogenesis may occur within hamartomas before spreading to the cortex and giving rise to secondary epileptogenic foci [6].

Source: Seizure: European Journal of Epilepsy - February 9, 2021 Category: Neurology Authors: Min Wang, Yi Zhang, Ping Xue, Yuanfeng Zhou, Wei Shi, Shuizhen Zhou, Yi Wang, Hao Li, Rui Zhao Source Type: research