Peripheral Blood Stem Cell Grafts in Allogeneic Hematopoietic Cell Transplantation: It is Not All About the CD34+ Cell Dose

Allogeneic Hematopoietic Cell Transplantation is a curative approach in various malignant and non-malignant disorders. The majority of adult transplants in the current era are performed using mobilized stem cells, harvested from the peripheral blood by leukapheresis. Peripheral blood stem cell (PBSC) collections are designed to target a dose of stem cells that will result in safe engraftment and hematopoietic recovery; however, 99% of the cells contained in a PBSC graft are not stem cells and a growing number of studies attempt to characterize the associations between graft composition and transplant outcomes.

Source: Transfusion and Apheresis Science - February 10, 2021 Category: Hematology Authors: Ran Reshef Source Type: research