My Approach to the Long QT Syndrome (LQTS)

Long QT syndrome (LQTS) is a potentially lethal cardiac disorder and thus must be dealt with respectfully. A nonchalant approach could lead to disaster. LQTS is a genetic disorder, with a prevalence of 1 in 2000 live births, characterized by a prolongation of the QT interval and by a propensity for life-threatening arrhythmias, especially, but not only, under conditions of physical or emotional stress. Mutations on at least 16 genes can cause LQTS but just three are in genetic subgroups important for clinical management because the conditions triggering the arrhythmic events (syncope, cardiac arrest, or sudden death) are largely gene-specific.

Source: Trends in Cardiovascular Medicine - February 6, 2015 Category: Cardiology Authors: Peter J. Schwartz Source Type: research